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Elimination of melatonin occurs mostly through hepatic metabolisation with cytochrome P450 enzyme CYP1A2 (see also Figure 5), followed by glucuronidation or sulfatidation (Tordjman et al., 2017)

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Periodontitis in elderly patients with type 2 diabetes mellitus: impact on gut microbiota and systemic inflammation

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The nutrient-dense composition also promotes a feeling of prolonged fullness, or satiety, which naturally reduces overall calorie intake and helps to prevent lean muscle mass loss during weight reduction